You may have heard of something called the entourage effect as it’s one of those buzz words that gets tossed around the CBD community quite often. But what exactly is the entourage effect, and why does it matter?
The Entourage Effect
The entourage effect is a concept first brought to the attention of cannabinoid researchers in 1998 when Dr. Raphael Mechoulam and Shimon Ben-Shabat suggested that the endocannabinoid system (ECS) exhibits an ‘entourage effect.’ According to the researchers, a variety of ‘inactive’ metabolites and related molecules have the ability to enhance activity of the primary endogenous cannabinoids: 2-AG and anandamide. In other words, these molecules and metabolites make your ECS work better.
They theorized that it is also this interaction that helps explain why whole plant compounds are more effective than isolated components. This means that all the different cannabinoids, terpenes and flavonoids found in the hemp plant work together in such a way that the combination of these compounds creates a stronger end result than any individual one does. Otherwise known as a ‘synergistic effect.’
Why the Entourage Effect Matters
According to the entourage effect, the other cannabinoids like THC, CBC and CBD boost the benefits of the CBD. Meaning, although the CBD alone can positively influence and affect your ECS, it also needs its “team” of other compounds to have maximum benefits.
But, it’s not only cannabinoids that add to this equation. Terpenes, too, have their particular own set of benefits. For instance, the terpene pinene was found to help counteract THC’s advert effects on memory and cognition. Terpenes also help our bodies absorb and process cannabinoids more effectively because they help increase their ability to cross the blood-brain barrier.
Examples of the Entourage Effect
A study of human breast cancer cells showed that full-spectrum cannabis extracts are more beneficial at reducing tumor size than pure THC alone. The researchers concluded that small amounts of other cannabinoids such as CBG and THCa working together to increase the effects of the THC.
In a study investigating CBD’s anticonvulsant effects, the researchers compared the results of five different types of cannabis extracts on seizure activity in rats. These extracts all had the same amount of CBD but different cannabinoid and terpene profiles. Their results showed remarkable differences between the effectiveness of the different extracts. Different cannabinoids and terpene profiles had different effects on the development of seizures as well as survival rates. This not only highlights the importance of the entourage effect, but also how different combinations and concentrations can make a difference.
Is a Full-Spectrum CBD Oil Always Better?
From this, it’s tempting to jump to the conclusion that a full-spectrum oil is the only way to go, but this is not always the case. The ability of different cannabinoids and terpenes to work together with each other as well as your ECS is not always a good thing because it can sometimes result in what cannabinoid scientists call a “chemical chaos” that isn’t needed or desired.
Each hemp plant is different, even plants from the same farm that are grown right next to each other can end up having different cannabinoid and terpene contents, rations and profiles. This can result in different compounds actually working against each other, which we want to avoid as much as possible.
However, in well-formulated, good quality CBD products, and when used as a supplement, you shouldn’t be too worried about this. In the end, there are so many other things to consider before you should decide which type of CBD oil is best for you. We’re all different, with our own physiological makeup, needs, and lifestyle, and this is what should determine the type of CBD oil you buy.
For instance, if you’re sensitive to other cannabinoids or need to go for regular drug testing, a full-spectrum CBD oil is not for you. Additonally, if you’re a patient that needs an exact dose of CBD, an isolate like Sativex is more accurate for precision dosing.
Knowledge of the synergy between the different cannabinoids, terpenes and other hemp plant compounds is growing daily, and as we learn more, this knowledge will continue to drive product development that will eventually result in CBD products that are developed for specific needs and effects.
The statements made regarding K’Dara CBD products have not been evaluated by the Food and Drug Administration nor had the efficacy of these products been confirmed by FDA-approved research.
None of the information on the K’Dara CBD website is intended to be an enticement to purchase and may not be construed as medical advice or instruction nor are the products mentioned or sold here intended to diagnose, treat, cure or prevent any disease.
All information presented is intended to be informative only, and not meant as a substitute for, or alternative to, information and/or diagnosis and/or treatment from registered healthcare practitioners.
We do not make any health claims about our products at K’Dara CBD. Always consult your healthcare professional about, usage, dosage, safety, potential interactions and/or other possible complications before using any product.
This disclaimer notice is provided as per the requirements of The Federal Food, Drug, and Cosmetic Act and the Food and Drug Administration.
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